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Lipid peroxidation, a hallmark of AD-related oxidative stress, generates reactive aldehydes like 4-hydroxynonenal (HNE), which modify proteins, including ATP synthase 68 , 69
Role of ferroptosis in non-alcoholic fatty liver disease and its implications for therapeutic strategies
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As a consequence of the stalling of Nrf2 ubiquitylation, and the resulting logjam, newly translated Nrf2 bypasses the CRL Keap1 complex and accumulates in the nucleus (see Fig
