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Description
AA147 covalently modifies KEAP1 to promote NRF2 activation in HT22 cells NRF2 activity is primarily regulated through its interaction with the redox sensor E3 ligase protein KEAP1 ( Fig

18.6%) or inhospital mortality (3.1% vs

In a recent smaller phase 1b study the non-steroidal, fexeramine-derived FXR agonist MET409 improved fat content (MRI-proton density fat fraction (PDFF)) over 12 weeks113 and is further evaluated alone or in combination with empagliflozin (SGLT2 inhibitor) in patients with both NASH and type 2 diabetes (NCT04702490)

J Comput Chem 31(2):455461
