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It is an important concept in pharmacology, as it helps to determine the dosage and frequency of drug administration
& Tappel, A
The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88
The treated cells showed markedly reduced lipogenesis
