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No lethal dose has been established, and animal models show a very high safety threshold

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[DOI] [PubMed] [Google Scholar] 38.Hatakeyama M., Opitz L., Russo G., Qi W., Schlapbach R., Rehrauer H

One of the key hormones to monitor during HRT is estradiol , a form of estrogen that plays essential roles in both male and female physiology
