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Dyslipidemia, hyperglycemia, along with other metabolic disorders, results in IR and/or islet cell dysfunction via some shared pathways, such as inflammation, endoplasmic reticulum stress (ERS), oxidative stress, and ectopic lipid deposition
doi: 10.1002/adma.202305300 43 JuL.CailinF.WenlanW.PinghuaY.JiayuG.JunboL
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Circulating IGFs are mainly associated with IGFBP-3 and acid labile subunit, forming a ternary complex which can dissociate allowing the IGF-IGFBP complex to pass through the vessels and reach target tissues (1)
