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In children with ASD, studies have demonstrated that glutathione metabolism can be improved with subcutaneously injected methylcobalamin and oral folinic acid (105), a vitamin and mineral supplement that includes antioxidants, co-enzyme Q10, and B vitamins ( N -acetyl-l-cysteine, a supplement that provides a precursor to glutathione, was effective in improving symptoms and behaviors associated with ASD ( Small (108) sized DPBC trials and small and medium-sized open-label clinical trials (108), sensory-motor symptoms ( N -acetyl-l-cysteine ( Several other treatments that have antioxidant properties ( These studies suggest that treatments that address oxidative stress may improve core and associated symptoms of ASD