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Clin Toxicol (Phila) 2012;50:2733

BPC-157 has no sequence overlap with other gut peptides and works in extremely tiny doses (micrograms to nanograms in animal studies)

(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug