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At the highest dose of 15mg, participants lost an average of 22.5% of their body weight over 72 weeks
In some patients free T4 may have to be above the reference range to achieve a normal TSH

Survodutide is a synthetic 29-amino-acid acylated peptide

Cell Biol Int 44(2):356367 Schlein R, Westendorf C, Krause G, Rosenthal W (2012) Functional significance of cleavable signal peptides of G protein-coupled receptors
