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VEGF and the regulation of angiogenesis
L-glutamate condenses with L-cysteine to form -L-glutamyl-L-cysteine, which requires GCS in presence of ATP, K + and Mg ++ with the formation of the enzyme bound -glutamyl-(P) as an intermediate.[9] -carboxyl group of glutamate form a peptide -linkage after reaction with the amino group of cysteine, which protects glutathione from hydrolysis by intracellular peptidase
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