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These include environmental pollution, chronic stress, poor diet, and even the natural process of ageing

Recent advances in targeted manipulation of the gut microbiome by prebiotics: From taxonomic composition to metabolic function

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By establishing molecular components associated with the Retromer demarcated retrieval sub-domain, we identify a previously unrecognised complexity in Retromers interface with RAB GTPases that we structurally and functionally dissect to reveal the retrieval sub-domain as a major hub for coordinating sequence-dependent cargo recognition and recycling with the regulated switching of a select group of RAB GTPases