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Studies indicate that A1AT therapy can lead to a reduction in systemic inflammation, as measured by lower CRP levels, thus potentially decreasing the overall inflammatory burden on the lungs ( Moreover, the reduction in inflammatory markers can also be indicative of the therapys effectiveness in mitigating the proteolytic damage caused by neutrophil elastase, which is typically unopposed in AATD patients due to low A1AT levels

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smegmatis has forced a rethinking on HGT and genome evolution among mycobacteria and provided a novel mechanism of bacterial HGT (42)

Fan et al., 2018), but studies are still needed to define the full dopaminergic system present in human microglia