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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

B12 supplementation during GLP-1 therapy makes physiological sense

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[100] It has been demonstrated that the activation of various reprogramming transcription factors, such as the Yamanaka factors Oct4, Sox, Klf4 and cMyc (OSKM), or chemical cocktails, can lead to the dedifferentiation of cells into pluripotent state, essentially reversing cell age