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Definitive evidence of the role of FFAs in GH-mediated insulin resistance was obtained in clinical studies in which the effects of exogenously administered GH on insulin resistance were abrogated by Acipimoxan inhibitor of lipolysis [185, 190, 191]

Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat

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Tirzepatide produced 33.9% fat mass loss in SURMOUNT-1
