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Preclinical research suggests DSIP influences sleep-wake cycles, circadian rhythm biology, and neurological signaling pathways

In this study we evaluated the applicability of the immortalized human cell line hCMEC/D3 for ABC transporter studies, focusing on the most expressed ABC transporters at the human BBB: P-glycoprotein (PGP, ABCB1), multidrug resistance protein 4 (MRP4, ABCC4) and breast cancer resistance protein (BCRP, ABCG2)

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Moreover, earlier it was shown that AEDG peptide involved in the regulation of proliferation and differentiation processes in various types of cells and tissues demonstrated geroprotective effects in animal models