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CYP2D6 Genetic Variability: Ultra-Rapid Metabolizers Some individuals may be ultra-rapid metabolizers because of a specific CYP2D6 genotype (e.g., gene duplications denoted as *1/*1xN or *1/*2xN)

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Proteomics Clin Appl 3: 682693, 2009

This vasodilator increases the availability of inflammatory mediators (TNF-, L-selectin) which, at high concentrations, can damage epithelial cells and lead to bronchial contraction (101)