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Defective hepatic autophagy in obesity promotes er stress and causes insulin resistance
Moreover, p53 plays a role in modulating cellular metabolism and influences the progression of ocular disorders such as DR through its influence on blood glucose regulation and fatty acid metabolism (86)
Modulating proposed electron transfer pathways in P450(BM3) led to improved activity and coupling efficiency
The same fate is fulfilled with the upregulation of IRPs [98, 99], the downregulation of FPN1 [100, 101], and the increased production of hepcidin, trapping more iron within cells [102]
