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30% Argireline (Acetyl Hexapeptide-8) Clinically studied at a 10% concentration of a 1% solution to visibly reduce wrinkle depth appearance by 30% over 30 days

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Clarke JR, Lyra E, Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazo R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG (2015) Alzheimer-associated A oligomers impact the central nervous system to induce peripheral metabolic deregulation