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Description
Orbitrap-based ultra-high-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) in data-dependent acquisition (DDA) mode was utilized to detect both phase-I and phase-II reaction products, together with in silico prediction and a home-made HbS-PI biotransformation database for in-depth metabolite screening

This reduction coincides with a noticeable decrease in regenerative capacity across all tissues, including bone

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The most common are mild and temporary
