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According to guidelines, negative test results should be confirmed by analyzing three different samples collected on alternate days [28]

Differentially expressed genes, proteins, lipids, and metabolites were separately analyzed using Ingenuity Pathway Analysis (IPA, Ingenuity System) against a reference background of whole genome in animal and human to identify changes in biological pathways for each omics dataset

The' nitric oxide (NO) scavenging activity was determined as described by Awah and Verla 30 while hydroxyl radical (OH) scavenging activity was measured using the method described by Gulcin et al

J Clin Psychopharmacol (2007) 27:26372