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however, due to the small number of both randomized or observational trials, further research has to be conducted on the method (Manchikanti et al., 2013)

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Gabrilovich DI, Ostrand-Rosenberg S, Bronte V

The literature includes mechanistic work and topical cosmetic studies, but the hub avoids turning that into guaranteed outcomes because study quality and relevance vary by formulation and context

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