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In WD, excessive intracellular copper accumulation inhibits the activity of key antioxidant enzymes, including SOD, thereby compromising the cellular capacity to neutralize ROS (99)

10.1105/tpc.1.7.707 100 SchuppR.RennenbergH

Hence, the different phosphorylation states of USP20 may lead to trafficking bias in the lysosomal sorting of the two major AR subtypes (Bristow et al., 1982
