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Areas of uncertainty in toxicity values generally include extrapolation from controlled high-dose animal studies to the human general population (including potentially sensitive subgroups) and generally lower exposure levels, determining if rodent endpoints are relevant to humans (e.g., tumors in the Zymbals gland of rodents), route-to-route extrapolation if toxicity values are lacking for certain exposure pathways, extrapolation from shorter-duration exposure studies to chronic or lifetime risk, and data gaps in the underlying toxicity database

Gao, F.J.S

Rice DC (1996) Evidence for delayed neurotoxicity produced by methylmercury

This adduct reaction is inhibited, and protein function maintained, by the presence of sulfhydryl compounds such as glutathione and L-cysteine [28,31], S -adenosyl-l-methionine [32], and the disulfide-containing garlic compound ajoene (( E )-1-(prop-2-enyldisulfanyl)-3-prop-2-enylsulfinylprop-1-ene) [33]