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High-throughput drug screens for amyotrophic lateral sclerosis drug discovery

When lysine is the substrate instead of glycine, the enzyme does not catalyze the synthesis of guanidinoacetate (Arg + Gly Orn + guanidinoacetate), the precursor of creatine, but the synthesis of homoarginine (Arg + Lys Orn + homoarginine)

[DOI] [PubMed] [Google Scholar] 25.Kraemer WJ, Volek JS, Spiering BA, et al

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