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Chloramphenicol (Chloromycetin): metabolized by cytochrome P450 to an alkylating metabolite that inactivates cytochrome P450 Other inactivators: Mechanism of Action: -- targeting the heme moiety: Steroids: Ethinyl estradiol (Estinyl) Norethindrone (Aygestin) Spironolactone (Aldactone) Others: Propylthiouracil Ethchlorvynol (Placidyl) Overview: Phase II reactions involve non-microsomal enzymes Reaction types: Conjugation Hydrolysis Oxidation Reduction Location (non-microsomal enzymes): primarily hepatic (liver)

doi: 10.1016/j.cyto.2014.09.011 270 BerraondoPSanmamedMFOchoaMCEtxeberriaIAznarMAPrez-GraciaJLet al

Musa HH, Musa TH, Musa IH

Moderate chronic kidney disease and cognitive function in adults 20 to 59 years of age: Third National Health and Nutrition Examination Survey (NHANES III)