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Although CD8 + T cells may be more susceptible to ammonia under certain tumor microenvironments or immunosuppressive conditions, other immune cells (such as CD4 + T cells and macrophages)may also undergo cell death due to ammonia overload

Am J Pathol 172(2):486494 Khan KA et al (2017) Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface

The above explanations fit well with the observation that intracranial hypertension may be found in up to half of ME/CFS patients, most commonly in combination with joint hypermobility (Higgins et al., 2013