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These metabolic alterations provide a mechanistic link between chronic alcohol consumption and the development or exacerbation of acne, suggesting new therapeutic targets for acne vulgaris in individuals with alcohol use disorder [116]

There, the pleiotropic beneficial effect, along with cytoprotection concept implementation, regulation of the increasing angiogenesis, increased VEGF, increased egr-1 gene, increased NO, or eNOS stimulation, and counteraction of the increased free radical formation, occur through a network of closely interconnected pathways presented in this review (see Section 1, Section 2 and Section 3)

In summary, this review has identified several natural productssuch as Withania somnifera , Ocimum sanctum , curcumin, and Astragalus membranaceus that have demonstrated significant effects on thyroid function or pathology in preclinical models, with some like Astragalus and Dioscorea nipponica showing promise in preliminary clinical studies