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Specifically, our findings across both clinical cohorts and experimental models demonstrate that hepatic FPN downregulation in MASLD led to iron accumulation, which subsequently and profoundly altered hepatokine secretion profiles, particularly of fetuin-A and LECT2 via FoxO1 activation, ultimately promoting obesity, IR, and impaired thermogenesis

Furthermore, the activation of the PI3K-AKT pathway and generation of ROS during autophagy can stimulate vasculogenic mimicry in glioma stem cells [212]

This reduction compromises the skins innate immune defense capacity

Overall, excessive truncation and S129p may create a precarious cellular state, causing widespread and unpredictable cellular consequences by enhancing promiscuous interaction, sequestering essential cellular components, and promoting LB nucleation and growth (Fig