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Putative mechanisms by which vitamin D may be beneficial in FM include: Modulation of nociceptive transmission in skeletal muscles, and its deficiency may lead to hyperinnervation and hypersensitivity to musculoskeletal pain

These may include tests of overall cognition, like the mini-mental state examination (MMSE), especially when screening for cognitive impairment or dementia

The patient may experience weight loss and a loss of appetite

R., Campbell, B