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The role of amylin, a gut-brain axis hormone, in metabolic and neurological disorders
doi: 10.1345/aph.1L216
Jensen, Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors, Obes
The healthy participant population within the Simcyp simulator was modified to include ~17% intermediate CYP2D6 metabolizers and ~83% extensive CYP2D6 metabolizers based on the urinary log (dextromethorphan/dextrorphan) ratios of the clinical study participants (data not shown)
