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Drosophila studies showed 11-16% extension Telomerase activation: In vitro studies confirmed hTERT upregulation in human fetal fibroblasts and pulmonary cells, with treated cells exceeding the Hayflick limit by approximately 10 additional population doublings Telomere elongation: Direct measurements showed statistically significant telomere lengthening in treated cells Cancer incidence: Long-term animal studies showed reduced spontaneous tumor formation, partially addressing the telomerase-cancer concern 2025 validation: An independent study confirmed telomere-lengthening effects across multiple human cell lines, representing the first significant non-Khavinson replication Key limitations: The evidence base is dominated by a single research group

doi:10.1016/j.clnesp.2017.01.002

However, there is some data suggesting that early stress in Atlantic salmon will cause lasting effects on the intestinal microbiome (Uren Webster et al., 2021)

(2012) Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2