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doi: 10.3390/ijms23031532 59 ZhaoJLZhaoJJiaoHJ

For example, in a pilot clinical trial investigating MSM for osteoarthritis, participants took MSM for 12 weeks with positive outcomes and minimal side effects reported

A recent study showed that kombucha exerted potent cytotoxic and apoptosis-inducing effects against HepG2 liver cancer cells with no significant growth inhibition in normal cell lines [84]

The development of an APAP-induced DILI mouse model based on the mechanism by which N-acetyl-p-benzoquinone imine (NAPQI), a reactive metabolite of APAP, induces hepatotoxicity by depleting GSH, led to the discovery of the antidote N-acetylcysteine (NAC), which has been used clinically for over four decades [91]