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Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia

cerevisiae S288C using primers MET15 _fw and MET15 _rv and was integrated into yeast strain BY4741 to restore prototrophy for methionine

Inhibitors of this system reduce intracellular GSH levels by blocking cystine uptake, impairing GPX4 function and triggering ferroptosis (156)
