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Figure 1 Common pathways of pathogenesis: immune dysregulation, epigenomics, the microbiome Immune dysregulation Inflammation is an adaptive response to stressors that involves multiple physiological processes that include the innate and adaptive immune systems

[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Nasca C., Bigio B., Zelli D., de Angelis P., Lau T., Okamoto M., Soya H., Ni J., Brichta L., Greengard P., Neve R.L., Lee F.S., McEwen B.S

Although extensive achievements have been made in this community with several FDA-approved trials, there is still a long way to go from clinical popularization and translational application