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39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)

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9,36 Consequently, this induces a pseudo-first-pass effect that interferes with drug absorption 37 and negatively affects the pharmacokinetic and pharmacodynamic profiles of the drugs