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Cysteinyl leukotrienes are responsible for the hyperreactivity to stimuli and the airway and vascular smooth muscle contraction that occur in asthmatic, allergic, and hypersensitivity processes
Broutier, L., Mastrogiovanni, G., Verstegen, M

This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013

Lyme disease complicated by the Jarisch-Herxheimer reaction