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Description
Notably, in HEK293 cells, in LC culture and in midbrain DA neurons, the endogenous TAAR1 signals from an intracellular location and AMPH must enter the cell to activate the both PKA and RhoA signaling pathways
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Phase I metabolism reactions include N- and O-dealkylation, N- and S-oxidation, aliphatic and aromatic hydroxylation and deamination [135]

The approval also comes after a previous rejection in December 2023 linked to problems with a third-party contract manufacturer
