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However, under oxidative stress, Bach1 dissociates from the HO-1 promoter, and stress signals induce the dissociation of Nrf2 from Kelch-like ECH-associated protein 1 (Keap1), which then binds to AREs and initiates the downstream expression of oxidative stress-resistant HO-1 to prevent ROS-induced cellular damage and maintain the organisms antioxidant response (Zhang et al., 2019)

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doi: 10.3390/pharmaceutics14122719

Numerous investigations have shown that inulin effectively increases the production of ferritin, iron-related enzymes, and genes in enterocytes (68)