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In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide

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These findings were confirmed in vivo, in nude mice bearing U937 tumours coinjected with recombinant hGH and the NF-B -inducing anticancer drug daunorubicin, to avoid the in vivo toxicity of TNF-