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In a model mimicking severe nephritis, which is essentially 100 percent lethal to the kidneys in humans and deadly to the mouse model, with treatment there was instead an 80 percent survival of the mice

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That double draw is why its fatigue tends to arrive earlier and harder than on semaglutide or tirzepatide

The body adjusts to GLP-1 receptor agonist activity, and removing that activity abruptly is not the same as a planned discontinuation