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But what exactly are these dark circles, and why are they formed

When you have MTHFR gene mutations, you may also experience elevated plasma total homocysteine, which is an independent risk factor for various health issues, particularly cardiovascular disease

Contact your GP if: You have been found to have elevated B12 levels and have not received an explanation or follow-up plan You are taking high-dose B12 supplements without medical supervision You develop new symptoms whilst taking B12 supplements, particularly skin changes, persistent headaches, or gastrointestinal symptoms You have risk factors for liver disease (alcohol excess, viral hepatitis, obesity) and have elevated B12 You experience unexplained weight loss, night sweats, or persistent fatigue alongside elevated B12 Seek urgent medical attention if you experience: Jaundice (yellowing of skin or eyes) Severe abdominal pain or swelling Unexplained bruising or bleeding Confusion or altered consciousness Severe, persistent vomiting These symptoms may indicate serious underlying conditions such as acute liver failure, haematological emergencies, or other critical illness requiring immediate assessment

This can happen as the result of a problem known as functional vitamin B12 deficiency, where there's a problem with the proteins that help transport vitamin B12 between cells