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Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation[J] Dev

However, in healthy human subjects, the Arg16 polymorphism is associated with enhanced agonist-mediated desensitization to vasodilatation, and the Glu27 polymorphism correlates with increased agonist-mediated responsiveness (Dishy et al., 2001)

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