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[2] For most individuals taking standard B12 supplements as recommended by healthcare professionals, the risk of harmful effects remains extremely low

In de novo hypothyroid adults without cardiac disease, total daily doses of 20-25 mcg divided two or three times achieve physiologic free T3 levels for most patients

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55 A separate, phase 2, dose-escalation study found that by reducing the starting dose and increasing dose-escalation time to 8 weeks, gastrointestinal side effects could be reduced and study dropout rates were similar to that of placebo