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These findings come from controlled laboratory models and describe physical chemistry, not biological activity

Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

[10] Clinical studies have reported no harmful effects with chronic daily doses as high as 200 mg (many times the nutritional requirement), indicating a wide safety margin for this vitamin

Note that these two documented starting doses are worlds apart in size 150 mcg versus 2.5 mg is a roughly 17-fold difference