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Pro-inflammatory chemokines (e.g., CCL2, CCL3, CCL7, CXCL8, CXCL10 , and CXCL11 ) and C-C motif chemokine receptor ( CCR ) 7 were significantly upregulated, contributing to immune cell recruitment, antigen presentation, and antitumor responses 38,39,40,41,42,43

Preliminary findings after one year indicated the program was associated with reduced symptom severity and improved quality of life

Diagnostic criteria for and clinical review of melanonychia in Korean patients
