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MS 6 spectrum), respectively, revealed a L- O -Val-L-Val-D- O -Leu-D-Ala sequence of the tetradepsipeptide and unequivocally confirmed two 13 C-labeled carbon atoms in -hydroxy isovaleric acid (L- O -Val) and valine (L-Val), respectively (Fig

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Our collaborative work demonstrated that severe reactive astrocytes release excessive amounts of the inhibitory gliotransmitter GABA via bestrophin 1 (BEST1) channels, contributing to memory deficits and impairing synaptic plasticity 58,59