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Description
To explore the potential molecular mechanisms underlying the regulation of GSH metabolism by mitophagy, Signaling Pathways Project predicted TFs associated with 4 up-regulated genes involved in GSH synthesis (Gclm, Gss, Gclc, and Slc7a11) in P3O compared to controls
364 Moxibustion also improves synovial tissue by upregulating SLC7A11 and GPX4 expression, thereby reducing ferroptosis
300 (1), F167-176 (2011)
A large phase III, multicenter, placebo-controlled, double- masked clinical trial is being planned to test this hypothesis
