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Blocking Siglec-7/9 or removing sialic acids reduces TAM differentiation, while 2,3-sialic acid dendrimers modulate macrophage phenotypes via Siglec-9, enhancing immunosuppressive markers

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Thus, it needs to be cleared out quickly to prevent cell and DNA damage, which can lead to cancerous mutations.[ref] Two well-studied genetic variants have different ways of reaching the same endpoint: ~ an alcohol dehydrogenase (ADH1B) variant that speeds up the conversion to acetaldehyde, thus creating a buildup of acetaldehyde ~ an acetaldehyde dehydrogenase (ALDH2) variant that slows down the conversion from acetaldehyde to acetic acid, again creating a buildup of acetaldehyde