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doi: 10.1093/eurheartj/ehae563 2 KollerDPathakGAWendtFRTyleeDSLeveyDFOverstreetCet al
Besides neurons, NF-B transcription factors are abundant in glial cells and cerebral blood vessels and the diverse functions of NF-B also regulate the inflammatory reaction around the neuronal environment
This issue is further intensified by mitochondrial dysfunction, which impairs energy production and increases the creation of ROS
The pBos-SMC1-GFP, pBos-SMC3-GFP, and pBos-RAD21-GFP constructs were generated by replacing the H2B coding sequence with PCR-amplified coding sequences of SMC1, SMC3, and RAD21, respectively
