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Takeda K, Ishida A, Takahashi K, Ueda T
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
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Hence, maintenance of the antioxidant genes like aldehyde dehydrogenase (Aldh3a2), Glutathione and its precursor amino acids (Cysteine, glycine and glutamate) are essential for their protection from ferroptosis and blasts proliferation stress induced cell damages ( Further in- depth investigation on identifying the metabolic dependencies of de-novo and relapsed/refractory LSCs will increase our understanding of metabolic vulnerabilities and the survival strategy of leukemia cells
