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doi: 10.1111/acel.2015.14.issue-5 Summary Keywords oxidative stress, sperm dysfunction, reactive oxygen species, DNA fragmentation and male infertility, male infertility Citation Wang Y, Fu X and Li H (2025) Mechanisms of oxidative stress-induced sperm dysfunction

GSH (l--glutamyl-L-cysteinyl-glycine) synthesis is initiated by generation of -glutamylcysteine from glutamate and cysteine via the glutamate-cysteine ligase (GCL), and the subsequent addition of glycine by the activity of GSH synthetase (GSS) (Figure 1.3 and 3.4b) [101, 226, 297]